Desperate to secure her fading celebrity status, Elisabeth Sparkle (Demi Moore), undergoes a black-market medical procedure that promises self-actualization, but culminates in the spawning of Sue (Margaret Qualley), a bold and brash clone of her younger self that perpetuates its existence via weekly spinal taps. The pair are warned to respect their new symbiotic relationship or risk corrosive consequences. But as Sue starts reserving more time in the limelight at the behest of a slimeball executive (Dennis Quaid) and her own growing ambition, Sparkle is soon faced with an existential threat, one that engenders a wicked feud with her tulpa and a knock-down, drag-out battle to reclaim her autonomy.